Chronic Myeloid Leukemia Prognosis and Therapy: Criticisms and Perspectives

bcr breakpoint and prognosis of chronic phase chronic myeloid leukemia.

In a recent article, Morris et all concluded that the location of breakpoints within the breakpoint cluster region (BCR) of chromosome 22 does not influence the duration of chronic phase or survival in chronic myeloid leukemia (CML). This conclusion conflicted with two previous independent studies2,’ from our laboratories that associated a 3’ breakpoint with shortened chronic phase duration, bu...

BCR-ABL breakpoint and prognosis in chronic myeloid leukemia.

Relationship Between SOX17 Gene Expression and Prognosis in Acute Myeloid Leukemia

Background: Acute Myeloid Leukemia (AML) is a group of heterogeneous malignancies caused by defects in differentiation of hematopoietic cells. SRY-box containing gene 17(SOX17) is a transcription factor which plays an important role in several biological processes, including cardiogenesis, angiogenesis, and lymphopoiesis. Aberrant expression of SOX17 has been detected in solid tumors. This stud...

Modern Therapy of Chronic Myeloid Leukemia

Chronic myeloid leukemia is one of the most thoroughly studied and, undoubtedly, best understood neoplasms. There are about 4000 and 5000 new cases of CML every year in the USA. CML is a hematologic stem cell malignancy that typically evolves in 3 distinct clinical stages: chronic and accelerated phases and blast crisis. The chronic phase lasts several years and is characterized by accumulation...

Chronic Myeloid Leukaemia – The Choice of Therapy and Future Perspectives

Touch MEdical MEdia 155 Abstract Recently, the advent of imatinib has opened a new era in the treatment of chronic myeloid leukaemia (CML), leading to an impressive increase in overall survival rates. Today, many CML patients can expect to survive, if properly managed, likely similar to the general population. Recent progresses in CML stem cell biology have identified new leukogenetic pathways ...